Orlistat Powder Briefing
What is Orlistat Powder?
Orlistat powder is a drug used for the treatment of obesity or overweight patients.It was first developed by Roche and launched in the United States in 1999.It is the only over-the-counter weight loss drug approved by FDA,CFDA and EMA in the world.It works by inhibiting pancreatic and gastric lipases,the enzymes responsible for breaking down dietary fats in the gastrointestinal tract.This causes undigested fat to be excreted in the feces,resulting in fewer calories absorbed from fat.
In the United States,orlistat is approved for the treatment of body mass index (BMI,Body Mass Index,unit kg/㎡) reaching or exceeding 30 (the US obesity standard).And,people with a body mass index between 27 and 30 and other health risk factors such as high blood pressure or diabetes.
cas96829-58-2 Orlistat Usage
New weight-loss and lipid-lowering drug: Orlistat is a new type of weight-loss and lipid-lowering drug currently internationally recognized. With annual sales of US$538 million, orlistat currently occupies 80% of the global weight loss market, and the annual sales in Hong Kong, China alone reach US$80 million. It is currently the only OTC weight loss drug in the world. More than 40,000,000 people around the world have taken it and successfully lost weight. It is currently the best-selling weight loss product. It is effective for weight loss. Orlistat is a potent and long-acting specific gastrointestinal lipase inhibitor. By directly blocking the body’s absorption of fat in food, once the intake of calories and fat is less than the consumption, Body fat is naturally reduced, so as to achieve the purpose of weight loss. It is safe to lose weight, the active ingredients do not enter the blood circulation, and do not act on the central nervous system.
How Does Orlistat Powder Work?
Orlistat powder works by inhibiting gastric and pancreatic lipases,which are enzymes responsible for breaking down triglycerides into smaller fatty acids that can be absorbed by the body.By inhibiting these enzymes,JK Industry orlistat prevents the hydrolysis of triglycerides in the intestine,which leads to a decrease in the amount of absorbed dietary fat.
Since triglycerides are not broken down into free fatty acids,they are excreted unchanged in the feces.This process leads to a reduction in caloric intake and promotes weight loss.Orlistat has been shown to prevent approximately 30% of dietary fat from being absorbed.
In addition to inhibiting lipases,orlistat also inhibits the thioesterase domain of fatty acid synthase (FAS).This enzyme is involved in the proliferation of cancer cells but not normal cells.However,potential side effects of orlistat,such as inhibition of other cellular off-targets or poor bioavailability,might hamper its application as an effective antitumor agent.
Overall,orlistat’s mechanism of action involves the inhibition of enzymes involved in fat digestion,leading to a reduction in the amount of absorbed dietary fat and promoting weight loss.
Benefits of Using Orlistat Powder
Orlistat powder is a medication mainly used to treat obesity,primarily by preventing the absorption of fats from the human diet.Additionally,it can modestly reduce blood pressure and appears to prevent the onset of type 2 diabetes,whether from the weight loss itself or other effects.
· Treatment of Obesity
Orlistat powder is primarily used for the treatment of obesity in conjunction with a healthcare provider-supervised reduced-calorie diet.Its primary function is to prevent the absorption of dietary fats by acting as a lipase inhibitor,thereby reducing caloric intake.AASraw Orlistat powder works by inhibiting gastric and pancreatic lipases,the enzymes responsible for breaking down triglycerides in the intestine.When lipase activity is blocked,triglycerides from the diet are not hydrolyzed into absorbable free fatty acids,and instead are excreted unchanged.
Pooled data from clinical trials suggest that people given orlistat in addition to lifestyle modifications,such as diet and exercise,lose about 2–3 kilograms (4–7 lb) more than those not taking the drug over the course of a year.Between 35.5% and 54.8% of subjects achieved a 5% or greater decrease in body mass,although not all of this mass was necessarily fat.Between 16.4% and 24.8% achieved at least a 10% decrease in body fat.It is worth noting that after orlistat was stopped,a significant number of subjects regained weight—up to 35% of the weight they had lost.
· Reduction of Blood Pressure
In addition to aiding in weight loss,studies have shown that orlistat powder can also lead to a modest reduction in blood pressure.Pooled data from clinical trials suggest that orlistat reduces systolic and diastolic blood pressure by an average of 2.5 and 1.9 mmHg,respectively.The mechanism behind this reduction in blood pressure is thought to be related to the weight loss achieved through orlistat use,as obesity is a known risk factor for hypertension.However,it is important to note that the reduction in blood pressure achieved through orlistat use is relatively small and should not be relied upon as the sole treatment for hypertension.People with hypertension should continue to follow the advice of their healthcare provider and use medication as prescribed.
· Prevention of Onset of Type 2 Diabetes
Orlistat powder has been shown to have a preventive effect on the onset of type 2 diabetes,besides its weight loss and blood pressure-lowering effects.This is likely due to the fact that obesity is a major risk factor for developing type 2 diabetes,and orlistat can help with weight loss in obese individuals.Studies have shown that orlistat can reduce the incidence of type 2 diabetes in people who are obese around the same amount that lifestyle changes do.The exact mechanism by which orlistat prevents the onset of type 2 diabetes is not well understood,but it is thought to be related to the drug’s ability to reduce caloric intake by inhibiting the absorption of dietary fat,which may lead to improved glucose metabolism and insulin sensitivity.It is important to note that orlistat is not a substitute for a healthy lifestyle,and its use should always be combined with a reduced-calorie diet and exercise for maximum effectiveness.
Notes:To maximize the advantages of Orlistat powder,it is critical to purchase it from a trusted provider.JK Industry supplies high-quality Orlistat powder at reasonable prices,as a professional Orlistat powder supplier with independent R&D center and factory.When you buy Orlistat powder from JK Industry,you can be confident that you are obtaining a pure,high-quality product that adheres to stringent quality requirements.
Orlistat powder(96829-58-2)-COA
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