Table of Contents
ACE-031 Briefing:
Product Name | ACE 031 |
Also known as | ACE-031 Peptide |
Appearance | Freeze-Dried White Powder |
Standard | Pharmaceutical |
Purity | 99% |
Application Type | Injection |
Solubility | Soluble in water or 1% acetic acid |
Supplying Form | Lyophilized Powder I |
ACE-031 Description:
ACE-031 is intended for research purpose only. ACE-031 should not be used for human consumption, diagnostic, therapeutic procedures, agricultural and veterinary purposes. ACE-031 is a soluble fusion protein that has been shown to increase muscle mass and strength in research studies. ACE-031 is being studied as a treatment for metabolic diseases, renal neoplasms of childhood, cardiovascular anomalies, age-related muscle loss, and cancer treatment related muscle loss and neuromuscular diseases. ACE-031 is a biologic therapeutic, based on activin receptor type IIB (ActRIIB). The molecule inhibits signaling via the ActRIIB receptor binding and increase muscle mass and strength. ACE-031 is a recombinant fusion protein that is artificially synthesized by fusion of standard antibody and a portion of ActRIIB receptor. The recombinant fusion protein eliminates myostatin and other biomolecules that limit muscle strength or growth.
ACE-031, a soluble fusion protein based on the activin receptor type IIB (ActRIIB), is a biologic therapeutic that inhibits signaling through the ActRIIB receptor. By preventing signaling though ActRIIB, ACE-031 increases muscle mass and strength. In numerous and varied animal models of disease, ACE-031 significantly increased muscle mass and muscle strength. ACE-031, and a related molecule ACE-435, have shown encouraging preclinical results in animal models of age-related muscle loss, neuromuscular disease, cancer treatment-related muscle loss and metabolic diseases. ACE-031 is currently being studied in a Phase 1 multiple dose clinical trial in healthy volunteers. ACE-435 is expected to enter clinical trials in 2010. ACE 031 Muscle Mass and Muscle Power Gains. ACE-031 is an engineered decoy receptor used in attempts to treat children with Duchenne Muscular Dystrophy (DMD). The ACE-031 receptor circulates outside the muscle-fiber membrane. Because this receptor binds to myostatin, it lowers the amount of myostatin that can bind to the native receptor in the membrane (ActRIIB), preventing myostatin from delivering the muscle growth-limiting signal.
ACE-031 belongs to class of proteins of TGF-beta super family that regulate muscle growth. ACE-031 acts on the molecular switches of these molecules and promote muscle growth. In experimental studies, ACE-031 promotes muscle growth and inhibits ActRIIB receptor signaling. In pre-clinical studies, administration of ACE-031 for two weeks increased skeletal muscle density, decreased leptin levels, and increased adiponectin. Some bodybuilders use ACE-031 to promote muscle growth and to improve lean muscle. No serious adverse events were reported after ACE-031. Most of the common adverse events are mild and tolerable. The polypeptide contains 368 amino acid molecules, which forms a very large polypeptide complex. Muscle growth is regulated by the production of amino acids , and TGF beta protein super family is mainly the regulator as indicated earlier the on and off switch mechanism is essential for muscle production. When ActRIIB receptors interact with the GDF-8, it sends an on signal, which in turn promotes muscle growth
ACE-031 Application:
Some bodybuilders use ACE-031 to promote muscle growth and improve lean muscle. ACE-031 No serious adverse events. Most common adverse events are mild and tolerant. The polypeptide contains 368 amino acid molecules that form a very large polypeptide complex. Muscle growth is regulated by the production of amino acids, and the TGFβ protein superfamily is primarily a regulator, and as mentioned above, the switch mechanism is essential for muscle production. When the ActRIIB receptor interacts with GDF-8, it emits an opening signal that promotes muscle growth.
ACE -031 Effect:
1. Fat loss and bone health
In the different studies conducted, the subjects experienced a decrease in leptin concentration and promoted adiponectin, which was a “good fat” hormone. So maybe Ace-031 does help to lose weight. Another study shows that the increase in alkaline phosphatase in blood and the reduction of collagen peptides; this may mean that it also helps to strengthen the bones.
2. Women weight loss
For overweight women were given a dose of 250 mg (mg) Ace 031. As a result, after one month, thigh muscle grew more than a pound. In addition, their lean weight increased by 3%, which is quite a result.
3. FSH
In the study with women, the concentration of FSH (follicle-stimulating hormone) decreased significantly and did not explain why. So there seems to be some side effects, we do not know whether men will happen the same thing. But we know that in the cattle, due to infertility, farmers refused to use Ace-031 “to strengthen” their stock.
ACE-031 Dosage:
Sportsmen taking 1 mg of ACE-031 once a week over the period of 3-4 weeks report nearly an immediate increase in the muscle hardness and the rapid growth of muscle mass and strength to an extent exceeding even the most efficient hardcore volume anabolic-androgenic steroid!
Another dosing option is to start with the dose of 200 mcg of ACE-031 per day and to increase the dose every week by 100 mcg, whereas the treatment cycle should last again 3-4 weeks. Once a cycle with ACE-031 is completed, a break in the duration of two weeks is recommended.
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