Table of Contents
Fulvestrant Powder Briefing:
Fulvestrant Powder is known as a hormonal breast cancer treatment. It is used to treat advanced breast cancer and metastatic breast cancer. Advanced breast cancer is cancer which has progressed despite treatment, and metastatic breast cancer is cancer which has spread into other parts of the body.
Many breast cancers need the female hormone oestrogen to grow. The cells of these cancers have tiny areas called receptors on their surface, which oestrogen can attach to. They are called ‘hormone receptor-positive’ cancers. Fulvestrant Powder works by blocking the receptors and this prevents oestrogen from reaching the cancer cells. This slows the growth of the cancer.
Chemical Names: Fulvestrant; Faslodex; 129453-61-8; ICI 182,780; Ici 182780; ICI-182780 More…
Molecular Formula: C32H47F5O3S
Molecular Weight: 606.777 g/mol
CAS: 129453-61-8
Density: 1.201 g/cm3
Melting Point: 104-106°C
Boiling Point: 674.8 °C at 760 mmHg
Appearance: white powder
Storage condition: 2-8°C
Usage: Antineoplastic (hormonal)
2D Structure:
Fulvestrant Powder treatment caused a significant decrease in MDM2 protein expression in human breast cancer cell lines MCF7 and T47D, and that the reduction of MDM2 correlated with the decrease in ER expression
Fulvestrant Powder enhances the sensitivity of human breast cancer cells to chemotherapeutic drugs. CompuSyn analyses showed that combined use of doxorubicin, paclitaxel or etoposide with fulvestrant resulted in different degrees of synergism in MCF7 and T47D cell lines tested. Besides, Combination of fulvestrant and chemotherapeutic drugs induces altered cell cycle distribution, apoptosis, and senescenc
COA:
| Test Item | Specification | Results | |
| Appearance | A white to off-white crystalline powder | A white crystalline powder | |
| Identification | IR | Conform | |
| Any Individual impurity | Not more than 0.10% | 0.18% | |
| Total impurities | Not more than 1.0% | 0.44% | |
| Ratio of isomers | 50.0%-60.0% | 51.70% | |
| 40.0%-50.0% | 47.86% | ||
| Purity | 99.0% | 99.56% | |
Fulvestrant Powder Usage:
Fulvestrant Powder is used to treat breast cancer that has spread to other areas of the body in women who have gone through “the change of life” (menopause). It is used in patients who have not responded well to other medications (e.g., tamoxifen). Breast cancer cells need the hormone estrogen in order to grow. Fulvestrant Powder works by blocking the effect of estrogen, slowing tumor cell growth.
How Fulvestrant Powder Works:
Many breast cancers are stimulated to grow by the female sex hormones oestrogen and progesterone. These breast cancers are called hormone sensitive or hormone receptor positive. Drugs that block the effects of these hormones can slow or stop the growth of the breast cancer cells. Fulvestrant stops oestrogen getting to the cancer cells by blocking oestrogen receptors and reducing the number of receptors the cancer cells have.
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