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Nootropic Selank Powder Briefing
Selank is a synthetic tuftsin analogue.
Synonyms:L-Proline, L-threonyl-L-lysyl-L-prolyl-L-arginyl-L-prolylglycyl-
Selank is a nootropic, anxiolytic peptide based drug developed by the Institute of Molecular Genetics of the Russian Academy of Sciences. Selank is a heptapeptide with the sequence Thr-Lys-Pro-Arg-Pro-Gly-Pro. It is a synthetic analogue of a human tetrapeptide tuftsin.
| Selank Name | Selank |
| Selank Other name | Nootropic Anxiolytic Peptide |
| Selank CAS | 129954-34-3 |
| Selank Molecular Formula | C33h57n11o9 |
| Selank Molecular Weight | 751.9 |
| Selank Assay | 99% Min. |
| Selank Character | White Lyophilized Powder |
Nootropic Selank Powder Usage:
1.While Selank is classified as a nootropic-anxiolytic type drug, it uses extend beyond the relief of anxiety and improved cognitive functioning alone. A few areas in which Selank may find itself useful are: Stress reduction, the alleviation of depression, reversal of anhedonia, improvement in mood in emotionally stable individuals, and cessation of insomnia.
2.Of course, with Selank being a nootropic-anxiolytic, it may also prove useful for the treatment of different forms of anxiety, such as G. A. D (generalized anxiety disorder), S. A. D (social anxiety disorder), Panic Disorder, as well as non-diagnosed bouts of anxiety. As a nootropic, Selank can help enhance mental sharpness, reduce mental fatigue, improve the ability to focus, improve cognitive functioning while in a sleep deficit, and enhance memory.
3.These effects are provided without the negative side effects typically associated , such as physical dependence, psychological addiction, and decreased motor ability. In fact, Selank is largely devoid of side effects, with the large majority of researchers claiming that it is a “side effect free” compound. This makes Selank more suitable for long-term use.
Selank's Mechanism of Action:
Selank appears to exert its effects through dopamine, serotonin and norepinephrine modulation while also having potent effects on the immune system.
A rodent study showed a 0.3mg/kg injection of Selank was able to increase norepinephrine and serotonin in various regions of the brain, including the hippocampus and frontal cortex
A similar study noted an increase of serotonin metabolism in the hypothalamus 30-120 minutes after 0.3mg/kg injection into rodents
A third study demonstrated selank was able to prevent hypoxia induced decreases in serotonin and norepinephrine, which preserved normal behavior
Interestingly, when compared directly to tuftsin, the endogenous peptide that selank is based upon, selank would appear superior. A rodent study which sought to block the synthesis of serotonin with p-chlorophenylalanine saw enhanced serotonin levels with selank administration but no result with tuftsin. Clearly the PGP “tail” addition to the molecule somehow enhances its effects.
Selank dosage:
It’s always best to start with a low dose and gradually build up to your individual comfortable levels.
Research has shown that intranasal (nasal spray) delivery of Selank is rougly 9 times more effective than injectable. This is attributed to some of it being able to bypass the blood-brain barrier.
1. Selank as nasal spray or drops (more effective):
duration: from 10 days to as long as needed
dosage: between 400 mcg – 9 mg of Selank per day
daily frequency:total daily dosage split into 3 doses throughout the day
2. Injectable Selank use (less effective):
duration: from 10 days to as long as needed
dosage: between 250 mcg – 3 mg per day
frequency of injection:1 injection per day for low dose, 2 injections for higher dose (divided between morning and late afternoon injection)
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