Table of Contents
Sermorelin Briefing
Sermorelin CAS 86168-78-7 Sermorelin Acetate/Sermorelin
Alias:Somatoliberin,Sermorelin ,Sermorelinum,Sermorelina,Sermoreline
Sequence: H-Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Gly-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg-NH2
CAS No.: 86168-78-7
Molecular Formula: C149H246N44O42S
Sermorelin Molecular Weight: 3357.96
Sermorelin Purity (HPLC): 98.0%min.
Single Impurity (HPLC): 1.0%max
Amino Acid Composition: ± 10% of theoretical
Peptide Content (N%): ≥ 80.0%
Water Content (Karl Fischer): ≤ 8.0%
Content (HPIC): ≤ 12.0%
MS (ESI): Consistent
Sermorelin Specific Rotation (20/D): -80.0~-90.0° (c=0.5 1%HAc)
Mass Balance: 95.0~105.0%
Sermorelin Appearance: White powder
Sermorelin is a GHRH (growth hormone-releasing hormone) peptide analogue. Its peptide
sequence is comprised of 29 amino acids. This sequence is a portion of the endogenous human
GHRH, and is currently considered to be the shortest synthetic peptide that possesses the full
array of functional GHRH activity. Due to this fact, sermorelin is considered to be a growth
hormone secretagogue.
Sermorelin has been used during research to stimulate the secretion of growth hormone from
the adenohypophysis (also called the anterior pituitary). The anterior pituitary secretes trophic
hormones. Sermorelin has also been used in research stimulation tests to assess for pituitary
sufficiency in relation to the secretion of the growth hormone.
How does it work?
Sermorelin is presented in a multi-dosed, injectable vial. Each vial contains a powder disc which contains 15mg (15,000 micrograms) of lyophilized Sermorelin Acetate. The vial is vacuum sealed by the pharmacy for your protection and for the preservation of the hormone peptide. Each Sermorelin vial also comes with a bottle of Bacteriostatic Water as a diluent. The Bacteriostatic Water is mixed with the Sermorelin to provide solution for injection. Administration and storage instructions will be provided with your prescription.
How to use Sermorelin?
Sermorelin is injected into the body fat, subcutaneously, using a very small needle similar to what a diabetic uses to inject insulin. Injections are initially prescribed for every day and are decreased in frequency over time.
The best time to take Sermorelin is prior to bedtime. Growth Hormone is primarily released during sleep and most beneficial to the body’s recovery and repair during this time. Sermorelin has a promoting effect on sleep and can therefore make you tired if taken during the day.
The Sermorelin Acetate Peptide and HGH
Sermorelin Acetate, which shares similar structure to CJC-1295, is a bio-identical synthetic
hormone that is extremely effective in increasing the amount of HGH. Human Growth Hormone is
a hormone released by the body that controls the reproduction and growth of the cells and each of
the organs in the body.
At a young age, the body’s HGH production is most active while the growth rate is at its
highest point. After the age of 30, for every decade of life, there is a 14% reduction in HGH
production . By the age of 40, HGH production is about 40 percent of what it was at the age of 20.
With the further development of Growth Hormone Releasing Factors (GHRF), such as Modified
GRF 1-29, HGH production may possibly begin again by stimulating the pituitary gland.
Sermorelin Acetate and Related Research
Since 1980, scientists have been studying GHRH for many years. Dr. D. Rudman was testing
Sermorelin as a tool for anti-aging processes and Dr. William Wehrenberg was looking at
different peptides and particularly GHRH to identify which part of it is needed for pituitary gland
stimulating response. His results after eliminating single amino acids showed that 29-acid-chains
were held responsible for pituitary stimulation. Many research studies have concluded that
Sermorelin is a well tolerated analogue of GHRH. As a result, this is suitable for use as a
provocative test of growth hormone deficiency (Prakash and Goa 1999). In 1999, both
researchers, Goa and Prakash checked Sermorelin Growth Hormone as provocative tasting
method for deficiency of endogenous G-hormone. Sermorelin therapy increased the volume of
hormone secreted by the stimulated pituitary gland, which is later converted by the liver into IGF-
1. The increased amount of IGF-1 in the blood stream leads to many benefits from the use of
Sermorelin: increasing metabolism and growth of new cells within the body’s organs and bones.
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