Spironolactone Powder Briefing
Spironolactone Powder, also known as spironolactone, is a kind of potassium preserving diuretic drug. It competes with aldosterone in the cortical epithelial cells of distal tubules and collecting ducts for the aldosterone receptor in the target cells, so as to inhibit the role of aldosterone in promoting sodium and potassium exchange, increase the excretion of sodium chloride and have a diuretic effect, while potassium ions can be retained. Therefore, spironolactone is a kind of potassium preserving diuretic drug.
Synonyms:
,(7alpha,17alpha)-;17alpha-Pregn-4-ene-21-carboxylicacid,17-hydroxy-7alpha-mercapto-3-oxo-,gamma-lactone,acetate;17-alpha-Pregn-4-ene-21-carboxylicacid,1-hydroxy-7-alpha-mercapto-3-oxo-alpha-lactone;17-alpha-pregn-4-ene-21-carboxylicacid,1-hydroxy-7-alpha-mercapto-3-oxo-alpha;17-Hydroxy-7alpha-mChemicalbookercapto-3-oxo-17alpha-pregn-4-ene-21-carboxylicacidgamma-lactoneacetate;17-hydroxy-7-alpha-mercapto-3-oxo-17-alpha-pregn-4-ene-21-carboxylicaciga;17-hydroxy-7alpha-mercapto-3-oxo-17alpha-pregn-4-ene-21-carboxylicacigamm;3-(3-keto-7-alpha-acetylthio-17-beta-hydroxy-4-androsten-17-alpha-yl)propion
The detailed specifications are as below:
| Items | Standard | Results |
| Appearance(Ph.Eur.) | A white or yellowish-white powder | White powder |
| Solubility(Ph.Eur.)(annual) | practically insoluble in water,soluble in ethanol (96 per cent) | Complies |
| Identification A.IR -spectrum(Ph.Eur.) A.IR -spectrum(USP) B.TLC(Ph.Eur.) B.UV Absorption(USP) C. Colour Reaction(Ph.Eur.) C.Precipitate reaction(USP) | meets the requirement meets the requirement meets the requirement meets the requirement meets the requirement meets the requirement | Complies Complies Complies Complies Complies Complies |
| Specific optical rotation (Ph.Eur.) (USP) | between -46° and -41° between -41° and -45° | -43.3° -43.7° |
| Loss on drying (Ph.Eur.) (USP) | not more than 0.5% not more than 0.5% | 0.14% 0.12% |
| Sulphated ash(Ph.Eur) | not more than 0.1% | 0.00% |
| Related substances(Ph.Eur.) Impurity A Impurity F Impurity C Impurity D Impurity E Impurity I Any unspecified impurity Total | not more than 0.2% not more than 0.3% not more than 0.2% not more than 0.15% not more than 0.3% not more than 0.5% not more than 0.10% not more than 0.7% | ND ND ND ND ND ND Complies 0.07% |
| Ordinary impurities(USP) | not more than 2.0% | Complies |
| Free thiol compounds(Ph.Eur.) | a blue colour develops | Complies |
| Free mercapto compounds(USP) | not more than 0.10ml | Complies |
| Assay HPLC (Ph.Eur.) HPLC (USP) | between 97.5 % and 102.0 % between 97.0 % and 103.0 % | 99.4% 100.1% |
| Residual solvent(In-house) Methanol Tetrahydrofuran DMF | not more than 3000ppm not more than 720ppm not more than 880ppm | 6ppm Less than LOD(0.4ppm) Less than LOD(43ppm) |
| Particle size(In-house) | 95% not more than 20 microns | Complies |
Application of Spironolactone Powder
It is mainly used as diuretic
Edema disease, combined with other diuretics, to treat congestive heart failure, cirrhosis ascites, renal edema and other edema diseases.
Hypertension, as an adjuvant treatment of hypertension.
Spironolactone can be used in the diagnosis and treatment of primary aldosteronism.
Prevention of hypokalemia
Aldactone removes excess fluid from the body in congestive heart failure, cirrhosis of the liver, and kidney disease.
It also can be used in combination with other drugs to treat elevated blood pressure, and for treating diuretic-induced low potassium (hypokalemia).
Aldactone also is used to counteract the effects of excessive adrenal aldosterone production (hyperaldosteronism). Aldosterone overproduction can occur from a tumor in the adrenal gland or enlarged adrenal glands (hyperplasia of the adrenal glands).
Spironolactone package
Spironolactone package:
1kg/Aluminum foil bag, 25kg/drum or according requirements.
Product,and clear&firm mark in every drum,including trademark,name,model, lot number,net weight,manufacturer ect…
Spironolactone storage:
It should be placed indoor where is dry& well-ventilated, room temperature is 5-25ºC, Stored in batches. do not near the power,prevent humid, avoid sun exposure.strictly prohibit storage with volatile chemicals to prevent adsorption modification.
Spironolactone shipping:
When transport KP line products shuld use clear conveyance and avoidmoisture, rain,sun and carry gentlyto prevent smash package.
How to process the order?
- send us an email toinfo@bulkrawspharma.com with the following details: product names, quantity and your special requests (eg. need custom produced)
- we quote and confirm your request details
- we ship your order after payment done and offer tracking code & packing pictures within 1-3 days
- we will keep you updated of your order status
- order received and review our services
Payment terms
MoneyGram, Western Union, Bitcoin,T/T Bank transfer,USDT.escrow alibaba (credit card,paypal),etc.
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