What is Cialis Powder Tadalafil?
Cialis Powder Tadalafil can relieve the muscles found in the vessel wall and increase blood flow to specific areas of the body.
In the name of Cialis, tadalafil Powder is used to treat erectile dysfunction (positive encece) and benign prostatic hyperplasia (prostate enlargement). Another brand of Dalarafil is Adcirca, which is used to treat pulmonary hypertension and improve the athletic ability of men and women.
In addition to your doctor tell you, do not take Cialis while taking Adcirca.
Cialis Powder Tadalafil can also be used for purposes not listed in this drug guide.
Erectile dysfunction is a common sexual arousal disorder in males affecting approximately 52 percent of men over the age of 18 years, worldwide. Varying in intensity, erectile dysfunction is usually caused by decreased blood flow to the penile blood vessels, which is the main step in the production of an erection.
Erectile dysfunction is a completely manageable and curable disorder with different medications targeting specialized enzymes in the wall of the penile blood vessels. One of the most potent medications for ED is Tadalafil powder with a half-life of 17.5 hours.
Cialis Powder Tadalafil testing results
| Test Items | Specification | Test Results |
| Appearance | White powder | Conforms |
| Test method | High pressure liquid chromatography(HPLC) | Conforms |
| Melting Point | 298-300°C | 301.5℃-302.6℃ |
| Loss on drying | ≤0.5% | 0.24% |
| Heavy metals(Pb) | ≤20ppm | 7.5ppm |
| Residue on ignition | ≤0.1% | 0.08% |
| Relative substance | ≤1.0% | 0.145% |
| Assay (on dried basis) | ≥98.5% | 99.33% |
| Conclusion | The product conform to USP 32. | |
Erectile dysfunction is a common sexual arousal disorder in males affecting approximately 52 percent of men over the age of 18 years, worldwide. Varying in intensity, erectile dysfunction is usually caused by decreased blood flow to the penile blood vessels, which is the main step in the production of an erection.
Erectile dysfunction is a completely manageable and curable disorder with different medications targeting specialized enzymes in the wall of the penile blood vessels. One of the most potent medications for ED is Tadalafil powder with a half-life of 17.5 hours.
Forms of Cialis Powder Tadalafil
Cialis Powder Tadalafil is a potent PDE5 inhibitor, available in different forms and dosages, making its consumption easier for patients. The medication is available in the form of pills or capsules, with the dosage being 5 mg, 10 mg, and 25 mg. It is important to note that the dosage of Tadalafil differs based on the manufacturing company.
Cialis Powder Tadalafil is also available in powder form, although it is mostly sold for industrial use. This is the main reason behind Tadalafil Powder wholesale shopping being quite famous with this form of the drug. This form is usually sold in containers of 25 kg to 50 kg, depending on the wholesale requirement.
The general dosage for Tadalafil powder, to start with, is 10 mg. The maximum dosage, within 24 hours, is 20 mg, and exceeding this dosage is not recommended.
This medication is safe for human consumption as it has received FDA approval and approval from Indian, Canadian, Australian, and British Health authorities. The FDA approved the use of Tadalafil pills in the year 2002, and soon after, tadalafil powder use was approved by FDA as well.
Cialis Powder Tadalafil manufacturer factory claims to manufacture the prescription-only medication with utmost precision. The manufacturers have the highest regard for human safety, which is made abundantly clear in the potency, safety, and efficacy of the final product.
Base Information of Cialis Powder Tadalafil
| Product Name | Cialis Powder Tadalafil |
| Chemical Name | (6R,12aR)-6-(1,3-benzodioxol-5-yl)-2,3,6,7,12,12a-hexahydro-2-methylpyrazino[1′,2′:1,6]pyrido[3,4-b]indole-1,4-dione |
| Brand Name | Cialis , Adcirca |
| Drug Class | PAH, PDE-5 Inhibitors; Phosphodiesterase-5 Enzyme Inhibitors |
| CAS Number | 171596-29-5 |
| InChIKey | WOXKDUGGOYFFRN-IIBYNOLFSA-N |
| Molecular Formula | C22H19N3O4 |
| Molecular Weight | 389.4 |
| Monoisotopic Mass | 389.138 g/mol |
| Melting Point | 298-300°C |
| Freezing Point | 2℃ |
| Biological Half-Life | 17.5 hours |
| Color | White to Off-White Cyrstalline Solid |
| Solubility | Soluble in DMSO (78 mg/ml at 25° C), methanol, water (< 1 mg/ml at 25° C), dichloromethane, and ethanol (< 1 mg/ml at 25° C) |
| Storage Temperature | Store at room temperature between 59°F and 86°F (15°C and 30°C). Don’t store this medication in moist or damp areas. |
| Tadalafil Application | Raw Tadalafil powder tablets, Sexual candy, Sex coffee, etc. |
How does Cialis Powder Tadalafil Work?
Cialis Powder contains Tadalafil, a PDE5 inhibitor compound that was initially researched and manufactured by GlaxoSmithKline after the discovery of Sildenafil, a similar compound. Sildenafil, on the other hand, was initially being researched as a treatment for angina and hypertension but the whole study was scrapped after failed results in the early phases of the study. However, upon review, it was found that Sildenafil may be able to produce erections if the patients were properly sexually stimulated.
As sildenafil is a PDE5 inhibitor, GlaxoSmithKline decided to perform a wide-range search into compounds with a similar mechanism of action as Sildenafil. This research led to the discovery and then the development of Tadalafil.
Cialis Powder Tadalafil is a potent PDE5 inhibitor with a half-life of 17.5 hours that takes approximately 96 hours to completely clear out of the human body. When compared to the common blue pill, Viagra, which is only effective for 3 hours to 4 hours after ingestion, Tadalafil comes out on the top.
The main mechanism of action of the drug is inhibiting the PDE5 enzyme that is present in the smooth muscle cells of the penile blood vessels. Inhibition of this enzyme results in vasodilation and eventually, increased blood flow through the blood vessels, which are surrounded by corpus cavernosa. This muscle of the penis, when put under strain by increased blood flow, is pressured into an erect position, which is referred to as an erection.
However, the penile muscles, corpus cavernosa to be exact, need to initially relax so the blood vessels can dilate and receive a high input of blood. This relaxation of the smooth muscles is also the effect of inhibition of the PDE5 enzyme, although indirectly. Inhibition of PDE5 results in an increased amount of Guanosine MonoPhosphate or GMP, which is important for the relaxation of smooth muscles, such as corpus cavernosa.
However, that is not the only use and mechanism of action of Tadalafil Powder. The prescription-only medication is also used for benign prostatic hyperplasia, a urinary disorder caused by enlargement of the prostate gland and presenting as painful urination. The mechanism of action for the treatment of enlarged prostate gland is also through the increased levels of GMP in the smooth muscle cells. Relaxation of these cells allows easier passage of urine and prevents urine retention and pain.
Tadalafil Powder is also prescribed for pulmonary arterial hypertension, as the PDE5 inhibiting effect not only increases the blood flow but also decreases the blood pressure, which is extremely beneficial in the treatment of PAH.
What Can Cialis Powder Tadalafil be Used For?
Cialis Powder Tadalafil is used for the treatment of the following conditions:
- Erectile Dysfunction
- Benign Prostatic Hyperplasia
- Pulmonary Arterial Hypertension
Although research is being conducted on new potential uses of the medication, currently it is only meant to be prescribed to men over the ages of 18 years, suffering from one of the disorders mentioned above. Most commonly, the medication is used for the treatment of erectile dysfunction.
Benefits of Cialis Powder Tadalafil
Cialis Powder Tadalafil has several benefits both on its own and when compared to other PDE5 inhibitors belonging to the class of sex stimulants drugs. This medication is potent and long-lasting as it takes 36 hours to be cleared from the system, only being virtually untraceable after 96 hours. The effects of the drug become apparent and visible around 20 minutes to 60 minutes after ingestion, and Tadalafil powder stays active for about 3 hours to 4 hours after. It is important to mention that the activity of the drug does not in any way equate to the duration of the erection.
Cialis Powder Tadalafil is incapable of producing spontaneous erections and needs appropriate sexual stimulation and arousal for it to be effective in producing an erection. If sexual stimulation is provided during the four hours following the ingestion of the medication, the drug can produce an erection and alleviate the symptoms of erectile dysfunction.
This sex stimulant drug is quite effective in treating erectile dysfunction as a result of its prolonged mechanism of action, which makes it the drug of choice for many suffering from erectile dysfunction and benign prostatic hyperplasia. Tadalafil Powder may be combined with Tamulsin, another potent drug for the treatment of benign prostatic hyperplasia although the efficacy of this drug mixture is still being studied and analyzed.
Appropriate Dosage of Cialis Powder Tadalafil
Cialis Powder Tadalafil, as mentioned above, is usually started off at 10 mg as the lowest dose possible. After at least a week of using the medication, the dose may be reduced, increased, or maintained at the same levels depending on the results. However, it is important to keep in mind that this medication is a prescription-only medication that should only be used when needed. It should also only be used once in 24 hours so as to not amplify the side effects of the medication.
The risk of a missed dose for a medication that should only be taken when needed is almost non-existent however, it is important to clarify the guidelines for a missed dose. This is because the medication is prescribed for daily use, at least three times a day when being used for the treatment of pulmonary artery hypertension and benign prostatic hyperplasia. In case of a missed dose, it is best to avoid that dosage completely, and under no circumstances should a missed dose be compensated with a double dose next time. This could lead to extremely prolonged and undesired effects that have the potential to result in nearly fatal complications.
Potential Side Effects of Cialis Powder Tadalafil
Cialis Powder Tadalafil, like most medications, has several common side effects associated with its use. However, none of them are serious, daily-life activities altering, or life-threatening. In fact, most of them will resolve on their own and will not require medical intervention.
The common side effects of Tadalafil include, but are not limited to:
- Stuffy nose
- Headaches
- Dyspepsia
- Stomach ache
- Flushing; warmth and redness of the skin
- Tinnitus; persistent ringing sound in the ear
- Hearing problems
- Blurry vision
- Loss of vision
- Priapism
Who Should Not Use Cialis Powder Tadalafil
Cialis Powder Tadalafil has various benefits and uses but it is specifically designed for the male gender, especially those over the age of 18 years. The medication should not be taken by women and children as they may be at higher risk of developing several of the common side effects and complications associated with Tadalafil Power use.
The following populations should not take Tadalafil Powder, or consult with their doctor before starting any medication belonging to the PDE5 inhibitors drug class:
- People with a history of surgical intervention within the last three months
- People with a history of cardiac events in the last three months to six months
- People with hypertension and hyperlipidemia
- People with renal diseases
- People with retinitis pigmentosa
- People with hemophilia or similar blood disorders
- People with multiple myeloma, or leukemia
- People with stomach ulcers
- People with a history of stroke or with increased risk of suffering a stroke
These people aren’t allowed to take Tadalafil because their current medications can interact with the drug, resulting in life-threatening complications. In some cases, these patients’ bodies may be more susceptible to the relatively common and non-serious side effects of the drug but the intensity of complications may be higher than usual.
Further Medical Research and Information
Cialis Powder Tadalafil is constantly being researched and studied to assess any other potential use of the medication. Tadalafil is the key compound in many different prescription drugs, all being sold under different brand names, mostly for disorders such as erectile dysfunction, benign prostatic hyperplasia, and pulmonary arterial hypertension. However, there are various studies that in their first phases have shown that Tadalafil, in the future, may be prescribed for other disorders as well.
One of the most important studies being performed on Tadalafil focuses on its efficacy and safety if used daily by patients suffering from erectile dysfunction. The study was published in an Indonesian Health Journal, and based on the researchers’ analysis of literature from electronic databases, it concluded that using Tadalafil once a day is more effective in treating erectile dysfunction than only using the medication when needed.
The reason why this study is so important is that it has the potential to change the treatment protocols for erectile dysfunction. However, further studies need to be performed before a change can be made in the treatment plans.
Another research into Tadalafil aims to repurpose the sex stimulant drug, along with a drug belonging to the same class, vardenafil, to be used in the treatment of bone disorders. The bone disorders here refer to disorders where osteoclast or bone-destroying cells are functioning at a higher speed and with efficiency unmatched to the functioning of the osteoblast or bone-forming cells. This results in decreased bone mass which makes patients susceptible to pathologic fractures.
The in vivo phase of the study showed that both of these drugs can not only increase the activity of osteoblasts but simultaneously decrease the activity of osteoclasts. The drugs are able to do this because the PDE5A pathway is key in producing a balance of both types of cells. The same pathway is what the drugs target for the treatment of erectile dysfunction. After the application of in vivo concepts on animal models by researchers leading this study, it was found that both drugs are viable options for the management of a healthy bone mass. However, further studies need to be conducted on the effects of both of the drugs on the bone mass of humans.
A meta-analysis published in the Endocrinology Journal compared the efficacy of tadalafil treatment, tamsulosin treatment, and tamsulosin plus tadalafil treatment in aiding the expulsion of urethral stones. The aim of the study was to not only find new combination therapies to help patients with ureteral stones but to also assess the safety of these treatment plans.
The use of Cialis Powder Tadalafil alone or tadalafil with tamsulosin were the two options that were found to be the most effective and least likely to produce an adverse effect. Moreover, the analgesic effects of Tadalafil may be able to alleviate the pain most patients with ureteral stones experience while the drug also helps expel the stone out of the system.
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