Telmisartan Powder Briefing
What is Telmisartan Powder ?
Telmisartan Powder is an angiotensin II receptor antagonist (angiotensin receptor blocker, ARB) used in the management of hypertension.Telmisartan, a novel antihypertensive drug, is a specific angiotensin receptor (AT type) antagonist for the treatment of essential hypertension. Alternative angiotensin receptors bind to AT receptor subtypes (known sites of action for angiotensin ) with high affinity. Telmisartan did not have any site agonist effect on the AT receptor site, but selectively bound to the AT receptor, and the binding effect was long-lasting.
Telmisartan, 4′-[(1,4′-dimethyl-2′-propyl[2,6′-bi-1H-benzimidazol]-1′-yl)methyl]-[1,1′-biphenyl]-2-carboxylic acid (Micardis), does not appear to bear any structuralrelationship to this class, but there is actually a great dealof overlap in the chemical architecture with other agents.
The first, and most significant, difference is the replacement of the acidic tetrazole system with a simple carboxylic acid. This acid, like the tetrazole, plays a role in receptor binding.
The second difference is the lack of a carboxylic acid near the imidazolenitrogen that also contributes to receptor binding.As with irbesartan, however, there is not a need for this groupto be acidic but, rather, to be one that participates in receptorbinding. The second ring, much like a purine basein deoxyribonucleic acid (DNA), can hydrogen bond with theangiotensin II receptor.
| Name | Telmisartan, CAS 144701-48-4 |
| Other names | Telmisartan 144701-48-4 BIBR 277 4′-((1,7′-Dimethyl-2′-propyl-1H,3’H-[2,5′-bibenzo[d]imidazol]-3′-yl)methyl)-[1,1′-biphenyl]-2-carboxylic acid |
| Key words | Pharmaceutical, drug, an angiotensin II receptor antagonist (ARB); used in the management of hypertension; |
| CAS number | 144701-48-4 |
| Molecular Formula | C33H30N4O2 |
| Molecular Weight | 514.629 g/mol |
| Chemical and Physical Properties | |
| Appearance | White or slightly yellowish, crystalline powder |
| Solubility | Practically insoluble in water |
| Quality standard | USP,EP |
| Application | |
| Drug Indication/Application/Use | Used alone or in combination with other classes of antihypertensives for the treatment of hypertension. Also used in the treatment of diabetic nephropathy in hypertensive patients with type 2 diabetes mellitus, as well as the treatment of congestive heart failure. |
| Formulations/Preparations | Tablet |
COA of Telmisartan Powder
Function of Telmisartan Powder
Telmisartan is a new type of blood pressure drugs, is a kind of specific angiotensin receptor II (AT I type)
antagonists, used in the treatment of primary hypertension.
A new antihypertensive drug, also a specific angiotensin receptor (AT) antagonist.
Compared with other antihypertensive drugs,Telmisartan with following characteristics:
The specificity of a receptor.
With significant antihypertensive action
With good diuretic effect.
Improve myocardial stenosis.
Application of Telmisartan Powder
Telmisartan is a new antihypertensive drugs, a specific angiotensin receptor (AT1 type) antagonist.
Telmisartan alternative angiotensin receptor binding with high affinity AT1 receptor subtype.
Telmisartan AT1 receptor sites in any part of agonist effects of telmisartan in combination with selective
AT1 receptors, the binding lasting effect. Buck stability does not cause coughing.
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