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Tetracaine Powder Briefing
Tetracaine Powder is an allosteric blocker of Ca2+ release at ryanodine receptors
Product Name: Tetracaine
Synonyms: 2-(Dimethylamino)ethyl 4-(butylamino)benzoate; 2-(Dimethylamino)ethyl p-(butylamino)benzoate; 2-Dimethylaminoethyl p-butylaminobenzoate; 2-Dimethylaminoethylester kyseliny p-butylaminobenzoove; 2-dimethylaminoethylesterkyselinyp-butylaminobenzoove; 2-dimethylaminoethylp-butylaminobenzoate;
CAS NO: 94-24-6
EINECS: 202-316-6
Molecular Formula: C15H24N2O2
Molecular Weight: 264.363
Refractive index 1.5800 (estimate)
Storage condition 2-8 ° C
Acidity coefficient (PKA) PKA 8.33 ± 0.03 (H2O t = 20.0, I = 0.10 (KCl)) (unknown)
Water solubility 156mg / L (temperature not stated)
What is Tetracaine powder?
Tetracaine Powder is a long-acting local anesthetic drug.
1. The penetration and local anesthesia effect of tetracaine are stronger than that of procaine, and the effect is lasting
2. It is mainly used for surface anesthesia, waist anesthesia, conduction block and epidural anesthesia
3. Generally not used for infiltration anesthesia,it is also toxic,10 times of procaine.
Tetracaine powder pharmacological mechanism
Block voltage dependent sodium channel, block conduction and produce anesthetic effect. Local anesthetics have lipophilic effect. The non dissociative type is the necessary condition for penetrating nerve. After penetrating nerve, it must be transformed into dissociative charged cation to play its role. The ratio of dissociated type to non dissociated type is different for different local anesthetics.
Tetracaine powder Pharmacology and Application
The effect of local anesthesia is stronger than procaine, which is 10 times greater than procaine. The toxicity was 10-12 times higher than that of procaine. It can pass through mucous membrane and is mainly used for mucous membrane anesthesia. The effect is rapid and takes effect in 1-3 minutes. 2-3 hours. 0.5% ～ 1% solution was used in Ophthalmology, without serious adverse reactions such as corneal injury. 1% ～ 2% solution should be used in the Department of rhinolaryngology, and the total amount should not exceed 20ml. Add 1 drop of 0.1% adrenaline hydrochloride solution to every 3 ml. 0.025% ～ 0.03% solution for infiltration anesthesia and 0.1% ～ 0.3% solution for nerve block. During spinal anesthesia, 10-15mg was mixed with cerebrospinal fluid and then injected with chemical book. Epidural anesthesia with 0.15% – 0.3% solution, when combined with lidocaine, the maximum concentration is 0.3%. Because of the greater toxicity, infiltration anesthesia is generally not done. Maximum: infiltration anesthesia, nerve block, once 0.1g.
Combined use of lidocaine tetracaine powder and dosage
Epidural block: the common concentration is 0.15-0.3% solution, which is combined with lidocaine hydrochloride, the highest concentration is 0.3%, the common amount is 40-50mg at a time, and the maximum is 80mg.
Subarachnoid block: its mixture (1% tetracaine hydrochloride 1ml mixed with 10% glucose injection 1ml and 3% ephedrine hydrochloride 1ml) is commonly used, with a common dosage of 10mg, 15mg as the limit and 20mg as the maximum.
Nerve block: 0.1% ～ 0.2%, 40 ～ 50mg, 100mg. Mucosal surface anesthesia: 1% isoosmotic solution is commonly used in Ophthalmology, 1-2% solution is used in Otolaryngology, and the limit is 40mg at a time.
Tetracaine powder side effects
The possible side effects of tetracaine powder. Ttracaine powder eye drops ay cause temporary redness, sting and burning.
The use of tetracaine powder ointment may cause skin allergy, mild burning sensation, skin scaling and other adverse effects. More serious side effects include swelling, severe burning or stinging. In addition, it may cause light sensitivity, eye moisture and irritation. If these side effects occur, the drug should be stopped immediately and see a doctor in time.
Tetracaine powder causes tachycardia or bradycardia, syncope, respiratory arrest or bradycardia, and emergency side effects are rare. Patients may have dizziness, drowsiness and neuroticism, as well as blurred vision and other problems. Excessive use may also have seizures, coma, arrhythmia and other symptoms.
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